Dr. Michael Lazar

The Mighty Cancer Fighting Properties of Feverfew

Researchers at the University of Birmingham have shown that it's possible to produce a compound with anti-cancer properties directly from feverfew -- a common flowering garden plant. The team was able to extract the compound from the flowers and modify it so it could be used to kill chronic lymphocytic cells in the laboratory. Feverfew is grown in many gardens, and also commonly sold in health food shops as a remedy for migraine and other aches and pains. The compound the researchers were investigating is called parthenolide and was identified by scientists as having anti-cancer properties several years ago. Although available commercially, it is extremely expensive with poor "drug-like" properties and has not progressed beyond basic research. Researchers were able to show a [...]

2019-08-10T16:24:08-07:00August 10th, 2019|

Optimizing prostate cancer treatment options with HIFU

Creating a customized plan optimized for a patient’s specific prostate needs is easier with Sonablate HIFU prostate ablation. “Did you know that prostate cancer can be treated without suffering the side effects of surgery and radiation? I am Dr. Michael Lazar, 4 time board certified urologist, who’s practiced in Santa Rosa for 36 years.  In 2007, I investigated and became an early user of a new technology for treatment of prostate cancer called high intensity focused ultrasound, or HIFU. This exciting non-invasive technology uses ultrasound energy to create heat.  This heat is precisely aimed at the cancerous portions of the gland to kill the cancer while sparing the normal regions.  It is painless, bloodless and causes much less erectile dysfunction and almost no [...]

2019-07-23T09:57:44-07:00July 23rd, 2019|

Protein identified that promotes aggressive prostate cancer

Study seeks to uncover new strategies to prevent or treat aggressive, late-stage prostate cancerProstate cancer represents a major health challenge and there is currently no effective treatment once it has advanced to the aggressive, metastatic stage. A new has revealed a key cellular mechanism that contributes to aggressive prostate cancer, and supporting a new clinical trial. The study was published in the journal Clinical Cancer Research.The research led by investigators at the Sidney Kimmel Cancer Center -- Jefferson Health (SKCC) and their collaborators at Memorial Sloan Kettering Cancer Center, the University of California, San Francisco, and Celgene Corporation, focused on an enzyme called DNA-PK (DNA-dependent protein kinase), a pivotal component of the cellular machinery that controls both DNA repair and influences gene expression. The [...]

2019-07-03T10:33:46-07:00July 3rd, 2019|

Cancer survival rate improving due to advances in treatment and early detection

There were more than 16.9 million Americans with a history of cancer on January 1, 2019, a number that is projected to reach more than 22.1 million by 2030 based on the growth and aging of the population alone, according to estimates from Cancer Treatment and Survivorship Statistics, 2019. The report is produced every three years by the American Cancer Society in collaboration with the National Cancer Institute to help the public health community better serve this growing population. It appears in CA: A Cancer Journal for Clinicians, with a companion consumer edition published as Cancer Treatment and Survivorship Facts & Figures. The number of cancer survivors continues to increase in the United States even as incidence rates are stable in women and declining [...]

2019-06-18T08:43:02-07:00June 18th, 2019|

Understanding how prostate cancer cells mimic bone may lead to new therapies

Prostate cancer often becomes lethal as it spreads to the bones, and the process behind this deadly feature could potentially be turned against it as a target for bone-targeting radiation and potential new therapies. In a study published online Tuesday in the journal PLOS ONE, Duke Cancer Institute researchers describe how prostate cancer cells develop the ability to mimic bone-forming cells called osteoblasts, enabling them to proliferate in the bone micro-environment. Attacking these cells with radium-233, a radioactive isotope that selectively targets cells in these bone metastases, has been shown to prolong patients' lives. But a better understanding of how radium works in the bone was needed. The mapping of this mimicking process could lead to a more effective use of radium-233 and to [...]

2019-06-04T08:14:20-07:00June 4th, 2019|

When HIFU is the Right Treatment Option for Prostate Cancer

Is HIFU Prostate Cancer Treatment for You? Since many men are diagnosed with early-stage prostate cancer, often, they must choose between a risky surgical intervention, no treatment at all, or simply monitoring the disease. Among the many treatment options available HIFU falls somewhere in the middle. HIFU, which stands for high intensity focused ultrasound, offers a less invasive, lower risk method of eliminating the prostate in the body with fewer complications. With HIFU physicians are able to target and treat small amounts of tissue, minimizing damage to nerves around the prostate responsible for preserving potency. HIFU is an FDA approved precise and targeted therapy that reduces the risk of complications caused by surgery and radiation. HIFU uses ultrasound energy, or sound waves, to heat and [...]

2019-05-14T09:32:18-07:00May 14th, 2019|

New Non-invasive Treatment for Prostate Cancer Adopted by Local Surgeon

*Urologist Robert Pugach, MD treated patients for over 10 years with HIFU before he underwent HIFU himself. Prostate cancer is a very common disease – about 1 in 9 men with be diagnosed in his lifetime. The good news is that it is also very treatable, especially if diagnosed early. Unfortunately, many traditional treatments for prostate cancer have a high risk of unwanted side effects which leave men with lifelong problems like loss of sexual function and urinary incontinence. However, a non-invasive treatment called HIFU is now available for men with localized prostate cancer: HIFU, which stands for High Intensity Focused Ultrasound, is as effective as surgery or radiation in eliminating cancer with lower risk of side effects. HIFU uses ultrasound energy to heat and [...]

2019-05-02T08:06:13-07:00May 2nd, 2019|

HIFU for prostate cancer offers better outcomes for life

Using high energy ultrasound beams to destroy prostate cancer tumors shown to be as effective as surgery or radiotherapy, but with fewer side effects. A study, carried out at six hospitals across the UK, tracked 625 men with prostate cancer who received a type of treatment called high-intensity focused ultrasound (HIFU). The research is the largest ever study of HIFU treatment used to target prostate tumors. The treatment is similar to a 'lumpectomy' for other cancers -- where doctors remove only tumor cells, leaving as much healthy tissue as possible. The findings, from a number of institutions including Imperial College London and University College London, found that after five years the cancer survival rate from HIFU was 100 per cent. Approximately, 1 in 10 [...]

2019-04-16T09:01:00-07:00April 16th, 2019|

United States sees the biggest drop in prostate cancer rate

Prostate cancer incidence and mortality rates are decreasing or stabilizing in most parts of the world, with the United States recording the biggest drop in incidence, according to results presented at the AACR Annual Meeting 2019, March 29-April 3. Despite the trend toward declining or stabilizing rates, prostate cancer remains the second most commonly diagnosed cancer and the sixth leading cause of cancer death among men worldwide, said the study's lead author, MaryBeth Freeman, MPH, senior associate scientist, Surveillance Research, at the American Cancer Society in Atlanta. "Previous studies have indicated significant variation in prostate cancer rates, due to factors including detection practices, availability of treatment, and genetic factors," Freeman said. "By comparing rates from different countries, we can assess differences in detection practices [...]

2019-04-09T08:34:29-07:00April 9th, 2019|

Compounds in coffee may inhibit the growth of prostate cancer

For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model; it has not yet been tested in humans. This work is presented at the European Association of Urology congress in Barcelona, after publication in the peer-reviewed journal The Prostate. Coffee is a complex mixture of compounds which has been shown to influence human health in both positive and negative ways. There is increasing evidence that drinking certain types of coffee is associated with a reduction in incidence of some cancers, including prostate cancers. Now Japanese scientists have studied the effects of two compounds found in coffee, [...]

2019-03-19T08:36:47-07:00March 19th, 2019|